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Anti -phospholipid syndrome Anti – Cardiolipin (IgG,IgM),

Anti – β۲ glycoprotein I (IgG,IgM), Lupus anti coagulant antibodies

Autoimmune hepatitis ANA,Anti- SMA,Anti- LKM-1 ,ANCA

Immune globulins,Anti- mitochondrial

antibodies

Primary biliary cirrhosis AMA,ANA,Anti-SS-A(RO), Anti-SMA –

Anti-centromere (ACA)

Primary sclerosing cholangitis P-ANCA , ANA

Celiac disease Anti- endomysial ( IgA, IgG), Anti-tissue

transglutaminase ( IgA, IgG) –

Anti-gliadin (DGP) ( IgA, IgG)

Dermatitis herpetiformis Anti- endomysial ( IgA, IgG), Anti- tissue

transglutaminase Ab( IgA, IgG)-

Anti-gliadin (DGP) ( IgA, IgG)

Inflamatory bowel disease ( IBD) (Ulcerative

colitis ,chron’s disease )

ANCA –ASCA (IgG,IgA)-

Calprotectin in stool

Behcet’s disease (Immune-mediated Systemic Vasculitis)

HLA-B51,( HLA B27)

Diabetes mellitus type 1 Anti-Glutamic acid decarboxylase (GADA) – Anti Islet cell (ICA)*

Pernicious anemia Anti-parietal cell antibodies (APCA)

Anti-intrinsic factor antibodies*

Good pasture’s syndrome / Nephritis Anti-glomerular Basement Membrane

(GBM) , ANCA (P- C)

Thyroid diseases ( AITD)

(Graves- Hashimoto’s Thyroiditis)

Thyroid Autoantibodies ( Anti TSHRAnti

TPO-Anti Tg)

Collagen diseases ANA, AMA,Anti-Cardiolipin,

Anti-dsDNA, ENA, Immune globulins

Lupus erythematosus ANA,Anti-ds-DNA (nucleosome), C1q, CIC, Anti C1q*, Anti-histone*, Anti- phospholipid, Anti- B2-glycoprotein, Anti-Cardiolipin (IgG,IgM)

Anti – SS-A (RO), SS-B(La), Anti-Sm, Anti-U1-snRNP

Mixed connective Tissue disease ANA, anti-U1-snRNP

Myasthenia gravis Anti-Acetylcholin receptor ,Anti-Musk

Myositis (Dermatomyositis,polymyositis) ANA, anti-jo 1, anti- U1- snRNP, Anti-SSA

(RO) Neuromeylitis optica (Devic’s syndrome) Anti-Aquaporin- 4 ( NMO- IgG )

Primary membraneous glomerulonephritis (PMGN) (Idiopathic) Anti-PLA2R (phospholipase A2 receptor ) Rheumatoid arthritis Anti-MCV, Anti-CCP (cyclic citrulinated peptide), Rheumatoid factor (IgGFc) CREST syndrome Anti-centromere-ANA-Anti-SCL-70 Scleroderma Anti – Scl-70, ANA, Anti-Centromere, Anti -U1- snPNP

Sjongren Syndrome Anti – SS-A(RO),Anti – SS-B(La), Anti- ds-DNA, Anti – U1-snRNP

Vasculitis (PAN, MPA, CSS,…) Sometimes ANCA-Anti-MPO, PR3 Wegener’S granulomatosis C-ANCA Anti- MPO(meyeloperoxidase) Anti- PR3 (proteinase 3)