New treatment for a major health problem
Obesity and related diseases, such as type 2 diabetes and fatty liver disease, are important global health factors, but researchers report that blocking RNA-silencing proteins in rat liver causes animals to lose fat and Be deprived of diabetes.
Dr. Takahisa Nakamura and colleagues at the Cincinnati Children’s Hospital Medical Center genetically removed the Argonaute 2 (Ago2) protein from the liver of mice. Ago2 protein controls RNA silencing in cells and affects energy metabolism in the body. Scientists report that when this protein stops RNA in the liver, it slows down the liver’s metabolism and the liver’s ability to eat a high-fat diet.
When they removed Ago2 from the rat liver, it was not toxic to the animals but stabilized energy metabolism. This helped prevent obesity and the development of diabetes and fatty liver disease, which can severely damage vital organs and eliminate toxins from the body.
“Although we are still at the beginning of the road, we suggest that there may be important applications for our findings in chronic metabolic disorders such as diabetes, fatty liver disease, and other diseases,” said Nakamura, a senior researcher and member of the International Department. Obesity-related, which allows us to find a new therapeutic approach that changes the energy balance in obesity and related diseases.
Scientists report that research is in its infancy. Their findings still need further study and validation in laboratory models and the development of a practical treatment for Ago2 inhibition in a clinical setting for patients. But the present article is a solid foundation for future work.